2 Results for "

Commiphora wightii

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Commiphora wightii" in MCE Product Catalog:

21
Guggulsterone
Guggulsterone
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21 Cited Publications
Cat. No.: HY-107738
CAS No.: 95975-55-6
Purity:  99.81%
Synonyms: Z/E-Guggulsterone
Category:  

Triterpenes Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy

Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .
Guggulsterone (Standard)
Guggulsterone (Standard)
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Cat. No.: HY-107738R
CAS No.: 95975-55-6
Synonyms: Z/E-Guggulsterone (Standard)
Category:  

Triterpenes Terpenoids Plants Burseraceae Commiphora wightii

Target:  

Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards

Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.
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